K-01-162-K162-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEK 01-162Cat. No.: HY-14533CAS No.: 677746-25-7Synonyms: K162分式: CHBrN分量: 288.18作靶點: Amyloid-作通路: Neuronal Signaling儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 14.29 mg/mL (49.59 mM; Nee

2、d ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 3.4701 mL 17.3503 mL 34.7005 mL5 mM 0.6940 mL 3.4701 mL 6.9401 mL10 mM 0.3470 mL 1.7350 mL 3.4701 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實驗結果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據(jù)儲存

3、條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 1.43 mg/mL (4.96 mM); Suspended solution; Need ultrasonic2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 1.43 mg/mL (4.96 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oil1/2 Mast

4、er of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 1.43 mg/mL (4.96 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 K 01-162 (K162) 結合到AO (-amyloid)將其破壞，EC50為80 nM。REFERENCES1. Li J, et al. Alzheimers disease drug candidates stabilize A- protein native structure by interacting with the hydrophobic core.

5、 Biophys J.2011 Feb 16;100(4):1076-82.2. Hong HS, et al. Candidate anti-A beta fluorene compounds selected from analogs of amyloid imaging agents. Neurobiol Aging. 2010Oct;31(10):1690-9.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-58955