Remdesivir-GS-5734-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemERemdesivirCat. No.: HY-104077CAS No.: 1809249-37-3Synonyms: GS-5734分式: CHNOP分量: 602.58作靶點(diǎn): SARS-CoV作通路: Anti-infection儲(chǔ)存式: Powder -20C 3 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 125 mg/mL (207.44 mM)* means solu

2、ble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 1.6595 mL 8.2977 mL 16.5953 mL5 mM 0.3319 mL 1.6595 mL 3.3191 mL10 mM 0.1660 mL 0.8298 mL 1.6595 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天

3、使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.17 mg/mL (3.60 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.17 mg/mL (3.60 mM); Clear solution3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oil1/2 Master of S

4、mall Molecules 您邊的抑制劑師www.MedChemESolubility: 2.17 mg/mL (3.60 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Remdesivir (GS-5734)種核苷類似物，具有抗病毒活性，在 HAE 細(xì)胞中，對(duì) SARS-CoV 和 MERS-CoV 的EC50 值為 74 nM，在延遲腦腫瘤細(xì)胞中，對(duì)肝炎病毒的 EC50 值為 30 nM。IC50 & Target EC50: 30 nM (murine hepatitis virus, delayed brain tumor cell), 74 n

5、M (SARS-CoV, HAE cell), 74 nM (MERS-CoV, HAE cell) 1體外研究 Remdesivir (GS-5734) is a potent antiviral agent. Remdesivir inhibits murine hepatitis virus (MHV) with anEC50 of 30 nM, and blocks SARS-CoV and MERS-CoV in HAE cells with EC50s of both 74 nM in HAE cellsafter treatment for 24 h 1.REFERENCES1.

6、 Agostini ML, et al. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and theProofreading Exoribonuclease. MBio. 2018 Mar 6;9(2). pii: e00221-18.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820