Ropinirole-hydrochloride-SKF-101468-hydrochloride-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemERopinirole hydrochlorideCat. No.: HY-B0623ACAS No.: 91374-20-8Synonyms: SKF 101468 hydrochloride分式: CHClNO分量: 296.84作靶點(diǎn): Dopamine Receptor作通路: GPCR/G Protein; Neuronal Signaling儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6

2、 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 17 mg/mL (57.27 mM; Need ultrasonic and warming)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 3.3688 mL 16.8441 mL 33.6882 mL5 mM 0.6738 mL 3.3688 mL 6.7376 mL10 mM 0.3369 mL 1.6844 mL 3.3688 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活

3、性 Ropinirole(SKF101468)鹽酸鹽是多巴胺受體D2抑制劑，IC50為29 nM。REFERENCES1. Eden, R.J., et al., Preclinical pharmacology of ropinirole (SK&F 101468-A) a novel dopamine D2 agonist. Pharmacol Biochem Behav,1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE1991. 38(1): p. 147-54.2. Iida, M., et al., Dopamine D2 recep

4、tor-mediated antioxidant and neuroprotective effects of ropinirole, a dopamine agonist. Brain Res,1999. 838(1-2): p. 51-9.3. Lam, Y.W., Clinical pharmacology of dopamine agonists. Pharmacotherapy, 2000. 20(1 Pt 2): p. 17S-25S.4. Allen, R., et al., Ropinirole decreases periodic leg movements and improves sleep parameters in patients with restless legs syndrome.Sleep, 2004. 27(5): p. 907-14.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;