Cloprostenol-sodium-salt-ICI-80996-sodium-salt-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECloprostenol sodium saltCat. No.: HY-108415CAS No.: 55028-72-3Synonyms: ICI 80996 sodium salt分式: CHClNaO分量: 446.9作靶點(diǎn): Prostaglandin Receptor作通路: GPCR/G Protein儲(chǔ)存式: 4C, sealed storage, away from moisture* In solvent : -80C, 6 mon

2、ths; -20C, 1 month (sealedstorage, away from moisture)溶解性數(shù)據(jù)體外實(shí)驗(yàn) H2O : 150 mg/mL (335.65 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.2376 mL 11.1882 mL 22.3764 mL5 mM 0.4475 mL 2.2376 mL 4.4753 mL10 mM 0.2238 mL 1.1188 mL 2.2376 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇

3、合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Cloprostenol sodium salt (ICI 80996 sodium salt)種合成的、有效的前列腺素類(lèi)似物，具有黃體溶解性1，為 PGF2 receptor 的激動(dòng)劑 2。IC50 & Target PGF2 receptor 2體外研究Cloprostenol is a PGF2 receptor agonist 2.1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemECloprostenol (0.1 M) counteract

4、s the adipogenic effects of statil, on both intracellular lipid accumulation andexpression of transcripts for proadipogenic factors C/EBP and PPAR after treatment for 6 days 2.體內(nèi)研究 Cloprostenol sodium salt (25 g) decreases plasma progesterone in pregnant rats 1.REFERENCES1. Salazar H, et al. Luteoly

5、tic effects of a prostaglandin analogue, cloprostenol (ICI 80,996), in rats: ultrastructural and biochemicalobservations. Biol Reprod. 1976 May;14(4):458-72.2. Pastel E, et al. Aldose reductases influence prostaglandin F2 levels and adipocyte differentiation in male mouse and human species.Endocrinology. 2015 May;156(5):1671-84.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 0