NSC-185058 - ATG4B 抑制劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemENSC 185058Cat. No.: HY-125169CAS No.: 39122-38-8分式: CHNS分量: 215.27作靶點(diǎn): Cathepsin; Autophagy作通路: Metabolic Enzyme/Protease; Autophagy儲(chǔ)存式: 4C, protect from light* In solvent : -80C, 6 months; -20C, 1 month (protect fromlight)溶解性數(shù)據(jù)

2、體外實(shí)驗(yàn) DMSO : 125 mg/mL (580.67 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 4.6453 mL 23.2266 mL 46.4533 mL5 mM 0.9291 mL 4.6453 mL 9.2907 mL10 mM 0.4645 mL 2.3227 mL 4.6453 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先

3、配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (9.66 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (9.66 mM); Clear solution3.

4、請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (9.66 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 NSC 185058種 ATG4B 抑制劑。ATG4B 種主 的半胱氨酸蛋酶 (cysteine protease)。NSC185058抑制 ATG4B 從顯著減弱噬 (autophagic) 活性 1。IC50 & Target ATG4B 1Autophagy 1體內(nèi)研究 NSC185058

5、 is an ATG4B antagonist. ATG4B stimulates autophagy by promoting autophagosome formationthrough reversible modification of ATG8. Inclusion of the ATG4B inhibitor NSC185058 enhances the anti-tumor activity of radiation therapy (RT). NSC185058 decreases glioblastoma (GBM) cell tumorigenicity, andenhan

6、ces the anti-tumor activity of RT when applied to orthotopic GBM xenograft models 1.REFERENCES1. Huang T, et al. MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma.Cancer Cell. 2017 Dec 11;32(6):840-855.e8.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400