CZC-54252 - LRRK2 抑制劑 - 生命科學(xué)試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECZC-54252Cat. No.: HY-B0792CAS No.: 1191911-27-9分式: CHClNOS分量: 504.99作靶點(diǎn): LRRK2作通路: Autophagy儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 21 mg/mL (41.58 mM; Need ultrasonic and warming)

2、Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 1.9802 mL 9.9012 mL 19.8024 mL5 mM 0.3960 mL 1.9802 mL 3.9605 mL10 mM 0.1980 mL 0.9901 mL 1.9802 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 CZC-54252LRRK2效抑制劑，對(duì)野型LRRK2和突變型G2019S LRRK2的IC50值分別為1.28和1.85nM。REFERENCES1. Ramsde

3、n N, et al. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinsons disease-related toxicity in human neurons. ACS Chem Biol. 2011 Oct 21;6(10):1021-8.2. Ramsden N, et al. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinsons disease-1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemErelated toxicity in human neurons. ACS Chem Biol. 2011 Oct 21;6(10):1021-8.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 021-5370