Gboxin - Oxidative Phosphorylation 抑制劑 - 生命科學試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEGboxinCat. No.: HY-111651CAS No.: 2101315-36-8分式: CHClNO分量: 392.96作靶點: ATP Synthase作通路: Membrane Transporter/Ion Channel儲存式: Powder -20C 3 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 32.5 mg/mL (82.71 mM; Need ultr

2、asonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.5448 mL 12.7239 mL 25.4479 mL5 mM 0.5090 mL 2.5448 mL 5.0896 mL10 mM 0.2545 mL 1.2724 mL 2.5448 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗 請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實驗結(jié)果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據(jù)儲存條件，適當

3、保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.17 mg/mL (5.52 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.17 mg/mL (5.52 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.17 mg/mL (5.52 mM);

4、Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 Gboxin種氧化磷酸化抑制劑，可靶向抑制膠質(zhì)母細胞瘤長。Gboxin 抑制 F0F1 ATP 合成 1。具有抗腫瘤活性 1。IC50 & Target F0F1 ATP synthase 1體外研究 Gboxin (0-15 M; 96 hours) specifically inhibit the growth of primary high-throughput GBM sphere (HTS)cells but no

5、t that of cycling primary low-passage mouse embryonic fibroblasts (MEFs) or astrocytes 1.Cell Viability Assay 1Cell Line: HTS cells, MEFs and astrocytesConcentration: 0, 185, 555, 1667, 5000, 15000 nMIncubation Time: 96 hoursResult: Inhibited the growth of HTS cells (IC50=150 nM).REFERENCES1. Shi Y, et al. Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma. Nature. 2019 Mar;567(7748):341-346.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-379