Ranolazine-dihydrochloride-CVT-303-dihydrochloride-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemERanolazine dihydrochlorideCat. No.: HY-17401CAS No.: 95635-56-6Synonyms: CVT 303 (dihydrochloride); RS 43285分式: CHClNO分量: 500.46作靶點(diǎn): Calcium Channel; Sodium Channel; Autophagy作通路: Membrane Transporter/Ion Channel; Neuronal Signa

2、ling;Autophagy儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 50 mg/mL (99.91 mM)H2O : 50 mg/mL (99.91 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 1.9982 mL 9.9908 mL 19.9816 mL5 mM 0.3996 mL 1.9982 mL 3.9963 mL

3、10 mM 0.1998 mL 0.9991 mL 1.9982 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Ranolazine dihydrochloride (CVT 303 dihydrochloride;RS-43285) 具有抗律失?；钚浴?/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE戶使本產(chǎn)品發(fā)表的科研獻(xiàn) Theranostics. 2018 Oct 29;8(19):5452-5468.See more customer valida

4、tions on HYPERLINK / www.MedChemEREFERENCES1. Hawwa N, Menon V. Ranolazine: Clinical Applications and Therapeutic Basis. Am J Cardiovasc Drugs. 2013 Jan 19.2. Keating GM. Ranolazine: A Review of Its Use as Add-On Therapy in Patients with Chronic Stable Angina Pectoris. Drugs. 2013Jan;73(1):55-73.3.

5、Wang WQ, Robertson C, Dhalla AK, Belardinelli L. Antitorsadogenic effects of (+/-)-N-(2,6-dimethyl-phenyl)-(42-hydroxy-3-(2-methoxyphenoxy)propyl-1-piperazine (ranolazine) in anesthetized rabbits. J Pharmacol Exp Ther. 2008 Jun;325(3):875-81. doi:10.1124/jpet.108.137729. Epub 2008 Mar 5.4. Shryock J

6、C, Belardinelli L. Inhibition of late sodium current to reduce electrical and mechanical dysfunction of ischaemic myocardium. BrJ Pharmacol. 2008 Mar;153(6):1128-32. Epub 2007 Dec 10.5. Zacharowski K, Blackburn B, Thiemermann C. Ranolazine, a partial fatty acid oxidation inhibitor, reduces myocardial infarct size andcardiac troponin T release in the rat. Eur J Pharmacol. 2001 Apr 20;418(1-2):105-10.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Te