1-Ethynylnaphthalene - Cytochrome P450 抑制劑 - 生命科學(xué)試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE1-EthynylnaphthaleneCat. No.: HY-111430CAS No.: 15727-65-8分式: CH分量: 152.19作靶點: Cytochrome P450作通路: Metabolic Enzyme/Protease儲存式: Pure form -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 125 mg/mL (821

2、.34 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 6.5707 mL 32.8537 mL 65.7073 mL5 mM 1.3141 mL 6.5707 mL 13.1415 mL10 mM 0.6571 mL 3.2854 mL 6.5707 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗請根據(jù)您的實驗動物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實驗結(jié)果的

3、可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (13.67 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (13.67 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90%

4、corn oil1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.08 mg/mL (13.67 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 1-Ethynylnaphthalene細(xì)胞素 P450 1B1 的選擇性抑制劑。IC50 & Target P450 1B1 1體外研究 1-Ethynylnaphthalene, selective inhibitor of cytochrome P450 IB1, does not affect 2-hydroxylation but

5、 inhibits4-hydroxylation by 38%. At higher concentrations, 1-Ethynylnaphthalene inhibits 2-hydroxylation of 2-Hydroxylation of estradiol (E2) by 30% and 4-hydroxylation of E2 by up to 80% 1.REFERENCES1. Liehr JG, et al. 4-Hydroxylation of estradiol by human uterine myometrium and myoma microsomes: implications for the mechanism ofuterine tumorigenesis. Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9220-4.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792