Ibotenic-acid-RS-Ibotenic-acid-DataSheet-生命科學試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEIbotenic acidCat. No.: HY-N2311CAS No.: 2552-55-8Synonyms: (RS)-Ibotenic acid; DL-Ibotenic acid分式: CHNO分量: 158.11作靶點: iGluR作通路: Membrane Transporter/Ion Channel; Neuronal Signaling儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80

2、C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 H2O : 6 mg/mL (37.95 mM; Need ultrasonic and warming)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 6.3247 mL 31.6236 mL 63.2471 mL5 mM 1.2649 mL 6.3247 mL 12.6494 mL10 mM 0.6325 mL 3.1624 mL 6.3247 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY

3、物活性 Ibotenic acid 對 N-甲-D-天冬氨酸 (NMDA) 和反式-ACPD 或代謝型使君氨酸 (Qm) 受體位點都具有激動劑活性。IC50 & Target NMDA receptor 1體外研究Ibotenic acid (Ibo) is capable of acting at both NMDA and trans-ACPD receptors in the CNS, although only1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEactivation of NMDA receptors is involved

4、 in Ibo neurotoxicity. Ibotenic acid is toxic to cortical neuronsexposes for 5 min with an EC50=77.38 M (n=5) as measured by release of lactate dehydrogenase to theculture media 1.REFERENCES1. Zinkand WC, et al. Ibotenic acid mediates neurotoxicity and phosphoinositide hydrolysis by independent receptormechanisms. MolChem Neuropathol. 1992 Feb-Apr;16(1-2):1-10.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fa