MK-3207 - CGRP Receptor Antagonist - 生命科學(xué)試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMK-3207Cat. No.: HY-10301CAS No.: 957118-49-9分式: CHFNO分量: 557.59作靶點(diǎn): CGRP Receptor作通路: GPCR/G Protein; Neuronal Signaling儲(chǔ)存式: 4C, stored under nitrogen* In solvent : -80C, 6 months; -20C, 1 month (stored undernitrogen)溶解性數(shù)據(jù)體外實(shí)驗(yàn)

2、DMSO : 100 mg/mL (179.34 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 1.7934 mL 8.9672 mL 17.9343 mL5 mM 0.3587 mL 1.7934 mL 3.5869 mL10 mM 0.1793 mL 0.8967 mL 1.7934 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍福渲魄罢?qǐng)先配制澄清的儲(chǔ)

3、備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (4.48 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (4.48 mM); Clear solution3. 請(qǐng)依序添加每種溶

4、劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (4.48 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 MK-3207服物相容性的CGRP受體拮抗劑，IC50和Ki分別為0.12 nM和0.024 nM，對(duì)AM1，AM2，CTR和AMY3的抑制性較弱。戶使本產(chǎn)品發(fā)表的科研獻(xiàn) Vascul Pharmacol. 2017 Mar;90:36-43. Eur J Pharmacol. 2018 Jun 15;829:8

5、5-92.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Salvatore CA, Moore EL, Calamari A, Pharmacological properties of MK-3207, a potent and orally active calcitonin gene-related peptidereceptor antagonist. J Pharmacol Exp Ther. 2010 Apr;333(1):152-60.2. Hewitt DJ, Aurora SK, Dodick DW, Randomized controlled trial of the CGRP receptor antagonist MK-3207 in the acute treatment ofmigraine. Cephalalgia. 2011 Apr;31(6):712-22.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3