Rostafuroxin-PST-2238-DataSheet-生命科學試劑-MedChemExpressVIP

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemERostafuroxinCat. No.: HY-12283CAS No.: 156722-18-8Synonyms: PST 2238分式: CHO分量: 374.51作靶點: Na+/K+ ATPase作通路: Membrane Transporter/Ion Channel儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 5

2、0 mg/mL (133.51 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.6702 mL 13.3508 mL 26.7016 mL5 mM 0.5340 mL 2.6702 mL 5.3403 mL10 mM 0.2670 mL 1.3351 mL 2.6702 mL請根據(jù)產品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內實驗請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加?/p>

3、溶劑(為保證實驗結果的可靠性，體內實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (6.68 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (6.68 mM); Clear solution1/2 Master of Small

4、Molecules 您邊的抑制劑師www.MedChemE3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (6.68 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Rostafuroxin（PST 2238）種抗壓化合物Na(addition)K ATPase拮抗劑；IC50為1.5 nM。REFERENCES1. Quadri L, et al. 17 beta-(3-furyl)-5 beta-androstane-3 beta, 14 beta, 17 alpha-triol (PST

5、 2238). A very potent antihypertensive agent witha novel mechanism of action. J Med Chem. 1997 May 23;40(11):1561-4.2. Ferrari P, et al. PST 2238: A new antihypertensive compound that modulates Na,K-ATPase in genetic hypertension. J Pharmacol ExpTher. 1999 Mar;288(3):1074-83.3. Ferrari P, et al. Ros

6、tafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain andadducin-dependent hypertension. Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R529-35.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820