GW791343-dihydrochloride - P2X Receptor 抑制劑 - 生命科學(xué)試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEGW791343 dihydrochlorideCat. No.: HY-15469CAS No.: 1019779-04-4分式: CHClFNO分量: 447.35作靶點(diǎn): P2X Receptor作通路: Membrane Transporter/Ion Channel儲(chǔ)存式: 4C, stored under nitrogen* In solvent : -80C, 6 months; -20C, 1 month (stored underni

2、trogen)溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 42 mg/mL (93.89 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.2354 mL 11.1769 mL 22.3539 mL5 mM 0.4471 mL 2.2354 mL 4.4708 mL10 mM 0.2235 mL 1.1177 mL 2.2354 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性

3、 GW791343 dihydrochlorideP2X7變構(gòu)調(diào)節(jié)劑，有種屬特異性，對(duì)P2X7的pIC50為6.9-7.2。REFERENCES1. Michel AD, et al. Identification of regions of the P2X(7) receptor that contribute to human and rat species differences in antagonisteffects. Br J Pharmacol, 2008, 155(5), 738-751.2. Felix RA, et al. Development of a comprehe

4、nsive set of P2 receptor pharmacological research compounds. Purinergic Signal, 2012,1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE8(Suppl 1), 101-112.3. Roman S, et al. Cloning and pharmacological characterization of the dog P2X7 receptor. Br J Pharmacol, 2009, 158(6), 1513-1526.4. Michel AD, et al. Negative and positive allosteric modulators of the P2X(7) receptor. Br J Pharmacol, 2008, 153(4), 737-750.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;/p>