Topiramate-McN-4853-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemETopiramateCat. No.: HY-B0122CAS No.: 97240-79-4Synonyms: McN 4853; RWJ 17021分式: CHNOS分量: 339.36作靶點(diǎn): mGluR作通路: GPCR/G Protein; Neuronal Signaling儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO

2、 : 100 mg/mL (294.67 mM)H2O : 4 mg/mL (11.79 mM; Need ultrasonic)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.9467 mL 14.7336 mL 29.4672 mL5 mM 0.5893 mL 2.9467 mL 5.8934 mL10 mM 0.2947 mL 1.4734 mL 2.9467 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。

3、體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (7.37 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)1/2 Master of Small M

4、olecules 您邊的抑制劑師www.MedChemESolubility: 2.5 mg/mL (7.37 mM); Clear solution3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (7.37 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Topiramate是鎮(zhèn)痙化合物，能拮抗GluR5受體，還可作為GABA受體介導(dǎo)的電流陽(yáng)性變構(gòu)調(diào)節(jié)劑。戶使本產(chǎn)品發(fā)表的科研獻(xiàn) Personalized Medicine Universe. 2019 May.See more custome

5、r validations on HYPERLINK / www.MedChemEREFERENCES1. Lyseng-Williamson KA, et al. Topiramate: a review of its use in the treatment of epilepsy. Drugs. 2007;67(15):2231-56.2. Nakamura J, et al. Target pharmacology of topiramate, a new antiepileptic drug. Nihon Yakurigaku Zasshi. 2000 Jan;115(1):53-7.3. Ormrod D, et al. Topiramate: a review of its use in childhood epilepsy. Paediatr Drugs. 2001;3(4):293-319.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-379