Cinnamaldehyde-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemECinnamaldehydeCat.No.:HY-N0609CASNo.:104-55-2分?式:C?H?O分?量:132.16作?靶點:Bacterial;Apoptosis作?通路:Anti-infection;Apoptosis儲存?式:-20°C,storedundernitrogen*Insolvent:-80°C,6months;-20°C,1month(storedunder

nitrogen)溶解性數(shù)據(jù)體外實驗DMSO:100mg/mL(756.66mM;Needultrasonic)H2O:<0.1mg/mL(insoluble)MassSolvent1mg5mg10mgConcentration制備儲備液1mM7.5666mL37.8329mL75.6659mL5mM1.5133mL7.5666mL15.1332mL10mM0.7567mL3.7833mL7.5666mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存?式和期限。體內(nèi)實驗請根據(jù)您的實驗動物和給藥?式選擇適當(dāng)?shù)娜芙?案，配制前請先配制澄的儲備液，再依次添加助溶劑(為保證實驗結(jié)果的可靠性，體內(nèi)實驗的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；澄的儲備液可以根據(jù)儲存條件，適當(dāng)保存；以下溶劑前的百分?指該溶劑在您配制終溶液中的體積占?)：1.請依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.5mg/mL(18.92mM);Clearsolution2.請依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:2.5mg/mL(18.92mM);Suspendedsolution;Needultrasonic3.請依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(18.92mM);Clearsolution1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemEBIOLOGICALACTIVITY?物活性Cinnamaldehyde?種主的?物活性化合物，從樟樹葉中分離得到。Cinnamaldehyde?種細(xì)胞因?產(chǎn)?抑制劑。Cinnamaldehyde具有抗、抗氧化、抗炎的特性。體外研究CinnamaldehydeinhibitsROSreleaseandtheactivationofMAPKsaswellaspro-inflammatorycytokinesexpressionwithinTLRsactivatedculturedmonocytes/macrophages[1].CinnamaldehydeinducesapoptosisbymitochondrialpermeabilitytransitioninhumanpromyelocyticleukemiaHL-60cells,andinducesapoptosisinhumanhepatomacellsthroughactivationoftheproapoptoticBcl-2familyproteins[1].REFERENCES[1].ChaoLK,etal.Cinnamaldehydeinhibitspro-inflammatorycytokinessecretionfrommonocytes/macrophagesthroughsuppressionofintracellularsignaling.FoodChemToxicol.2008;46(1):220‐231.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-82