Clodronic-acid-disodium-salt-Clodronate-disodium-salt-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemEClodronicaciddisodiumsaltCat.No.:HY-B0657ACASNo.:22560-50-5Synonyms:Clodronatedisodiumsalt分?式:CH?Cl?Na?O?P?分?量:288.86作?靶點(diǎn):Others作?通路:Others儲(chǔ)存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1monthBIOLOGICALACTIVITY?物活性Clodronicacid(Clodronate)disodiumsalt，第?代雙磷酸鹽，?種具有?服活性的破?細(xì)胞?吸收(osteoclasticboneresorption)的抑制劑。Clodronicaciddisodiumsalt可?于??轉(zhuǎn)換狀態(tài)、Paget’s病和溶?性?轉(zhuǎn)移中。體外研究Clodronicacid(Clodronate)disodiumsaltinducesrapidapoptosisinosteoclastsbypreventingtranslocationofADPintomitochondriaafterbeinginternalisedviaresorption.Consequently,ATPproductionisinhibited,leadingtoinductionofapoptosisbymeansofreleaseofcytochromeCintothecytoplasm[2].體內(nèi)研究Clodronicacid(Clodronate)disodiumsalt(6.25-25mg/kg;p.o.;dailyfor28days)slightlydecreasesthehindpawswellingatdosesof12.5and25mg/kg[3].AnimalModel:MaleLewisrats,aged7weeks[3]Dosage:6.25,12.5,and25mg/kgAdministration:P.o.;dailyfor28daysResult:Hindpawswellingwassignificantlysmallerthaninadjuvant-arthritis(AA)-controlat25mg/kgondays21and28(87and88%ofAA-control,respectively)andat12.5mg/kgonday28.1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemEREFERENCES[1].ItohF,etal.Effectsofclodronateandalendronateonlocalandsystemicchangesinbonemetabolisminratswithadjuvantarthritis.Inflammation.2004;28(1):15‐21.[2].M?nkk?nenJ,etal.Clodronate(dichloromethylenebisphosphonate)inhibitsLPS-stimulatedIL-6andTNFproductionbyRAW264cells.LifeSci.1994;54(14):PL229‐PL234.[3].TanakolR,etal.Clodronicacidinthetreatmentofpostmenopausalosteoporosis.ClinDrugInvestig.2007;27(6):419‐433.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820