Nacubactam-OP0595-free-acid-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemENacubactamCat.No.:HY-109008CASNo.:1452458-86-4Synonyms:OP0595freeacid分?式:C?H??N?O?S分?量:324.31作?靶點(diǎn):Bacterial作?通路:Anti-infection儲(chǔ)存?式:-20°C,protectfromlight,storedundernitrogen*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light,storedundernitrogen)溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:250mg/mL(770.87mM;Needultrasonic)H2O:35.71mg/mL(110.11mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM3.0835mL15.4173mL30.8347mL5mM0.6167mL3.0835mL6.1669mL10mM0.3083mL1.5417mL3.0835mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month(protectfromlight,storedundernitrogen)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請(qǐng)先按照InVitro?式配制澄的儲(chǔ)備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的?式助溶)1.請(qǐng)依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%saline1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemESolubility:≥2.08mg/mL(6.41mM);Clearsolution2.請(qǐng)依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.08mg/mL(6.41mM);Clearsolution3.請(qǐng)依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(6.41mM);Clearsolution4.請(qǐng)依序添加每種溶劑：PBSSolubility:100mg/mL(308.35mM);Clearsolution;NeedultrasonicBIOLOGICALACTIVITY?物活性Nacubactam(OP0595freeacid)?種有效的?β-內(nèi)酰胺-β-內(nèi)酰胺酶(non-β-lactam-β-lactamase)抑制劑，對(duì)A級(jí)和C級(jí)β-內(nèi)酰胺酶具有活性。Nacubactam(OP0595freeacid)?種霉素結(jié)合蛋?2活性抗菌劑，并使β-內(nèi)酰胺靶向其他霉素結(jié)合蛋?的β-內(nèi)酰胺獨(dú)?的增強(qiáng)作?[1][2]。IC50&Targetnon-β-lactam-β-lactamase[1]REFERENCES[1].MonogueML,etal.InVivoEfficacyofMeropenemwithaNovelNon-β-Lactam-β-LactamaseInhibitor,Nacubactam,againstGram-NegativeOrganismsExhibitingVariousResistanceMechanismsinaMurineComplicatedUrinaryTractInfectionModel.AntimicrobAgents[2].LivermoreDM,etal.ActivityofOP0595/β-lactamcombinationsagainstGram-negativebacteriawithextended-spectrum,AmpCandcarbapenem-hydrolysingβ-lactamases.JAntimicrobChemother.2015Nov;70(11):3032-41.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseon