腫瘤發(fā)病過程相關(guān)信號通路

腫瘤發(fā)病過程相關(guān)信號通路腫瘤發(fā)生BiochimicaetBiophysicaActa1775(2007)283–297腫瘤細胞形成過程腫瘤特征標(biāo)志Cell,Vol.100,57–70,January7,2000,HallmarksofcancerCell144,March4,2011表觀遺傳與癌癥信號通路與腫瘤發(fā)生異常的信號通路通常表現(xiàn)在：信號傳遞分子的突變信號傳遞分子的修飾水平改變信號傳遞分子的異常表達信號通路分子的異常激活蛋白激酶組學(xué)與疾病GroupNamesAGCContainingPKA,PKG,PKCfamilies;CAMKCalcium/calmodulin-dependentproteinkinase;CK1Caseinkinase1;

CMGCContainingCDK,MAPK,GSK3,CLKfamilies;

STEHomologsofyeastSterile7,Sterile11,Sterile20kinases;

TKTyrosinekinase;

TKLTyrosinekinase-like.腫瘤相關(guān)蛋白激酶突變腫瘤相關(guān)信號通路PI3K-AKTSignalingGPCRSignalingMAPKSignalingRasSignalingNF-kBSignalingJAK-STATSignalingTLRSignaling腫瘤細胞增殖相關(guān)腫瘤與免疫腫瘤相關(guān)信號通路WntSignalingHedgehogSignalingNotchSignalingTGF-βSignalingHippoSignaling腫瘤與發(fā)育腫瘤相關(guān)信號通路PI3K-AKTSignalingGPCRSignalingMAPKSignalingRasSignalingReceptor/NF-kBSignalingJAK-STATSignalingTLRSignaling腫瘤細胞增殖相關(guān)腫瘤與免疫PI3K-AKTsignalingAktrelatedsignalingnetworkThenodesofPI3K/AKTpathwayCancerTreatmentReviewsxxx(2012)Cell149,1098–1111,May25,2012CancerCell20,173–186,August16,2011GPCRsignaling

DiversityofG-protein-coupledreceptorsignallingNATUREREVIEWS|CANCERVOLUME7|FEBRUARY2007|79GPCRsdesensitizationa)antagonists;b)Antibodies;c)Bindingandquenchingtheagonist;d)Promotingarrestin(orange)dependentdesensitization;e)AnacylatedGPCRintracellularloop(magenta);f)Specificinhibitors(grey);g)Rinternalizationpromotestheendocytosisofradioligands(blue)andtoxins(brown);Pharmaceuticals2011,4,567-589TrendsinPharmacologicalSciences31(2010)434–441MAPKsignalingChemistry&Biology19,1093–1104,September21,2012RassignalingTrendsinMolecularMedicineJanuary2012,Vol.18,No.1腫瘤相關(guān)信號通路PI3K-AKTSignalingGPCRSignalingMAPKSignalingRasSignaling

NF-kBSignalingJAK-STATSignalingTLRSignaling腫瘤細胞增殖相關(guān)腫瘤與免疫JAK-STATSignalingNF-kBSignalingTLRSignalingNFkB通路ColdSpringHarb

Perspect

Biol2009NF-kBandIkBproteinsImmunologicalReviews2006Vol.210:171–186PanoramicviewofmiRNAsconvergedwiththeNF-kBnetworkJournalofMolecularCellBiology(2011),3,159–166TLR通路CurrentBiologyVol21No13TLR-mediatedimmuneresponsesCellDeathandDifferentiation(2006)13,816–825TLR3-andTLR4-mediatedsignalingpathwaysCellDeathandDifferentiation(2006)13,816–825TLR7/8-andTLR9-mediatedsignalingpathwayCellDeathandDifferentiation(2006)13,816–825JAK/STATsignalingNatureReviewCancer|November2009|volume9JAK/STATsignalingCellDivision2010,5:14CellDivision2010,5:14StrengthanddurationofSTAT3activationdeterminescellularresponsesSTAT3connectsinflammationandcancerNatureReviewCancer|November2009|volume9腫瘤相關(guān)信號通路WntSignalingHedgehogSignalingNotchSignalingTGF-βSignalingHipposignaling腫瘤與發(fā)育WntsignalingpathwayNuclearTCF/β-CateninCoactivatorComplexesDevelopmentalCell17,July21,2009Cell151,1–17,December21,2012NotchsignalingpathwayAlternativestrategiestoinhibitNotchsignalingincancertherapySeminarsinCell&DevelopmentalBiology23(2012)465–472CancerCell22,222–234,August14,2012HedgehogSignalingPathwayThecorecomponentsoftheHhpathway(Ptc/PTCH)

(Smo/SMOH)TrendsinMolecularMedicine1