NonLangerhansCellHistocytosesANewUnifying課件

1、感謝您本幻燈片內容包含挑選的圖像文件。 lippincott-raven publishers. ? lippincott williams & wilkins, inc.2table 1non-langerhans cell histiocytoses: a new unifying concept.zelger, b; sidoroff, a; orchard, g; cerio, ramerican journal of dermatopathology. 18(5):490-504, october 1996.table 1 . list of non-langerhans c

2、ell histiocytoses according to winkelmann (6) and gianotti and caputo (20) lippincott-raven publishers. ? lippincott williams & wilkins, inc.3fig. 1non-langerhans cell histiocytoses: a new unifying concept.zelger, b; sidoroff, a; orchard, g; cerio, ramerican journal of dermatopathology. 18(5):49

3、0-504, october 1996.fig. 1 . basic cytologic concept of non-langerhans cell histiocytoses revealing five mononuclear cell types: vacuolated, spindle shaped, xanthomatized, scalloped, and oncocytic histiocytes. various types of multinucleate histiocytes can be preferentially associated with this mono

4、nuclear histiocytes: touton to xanthomatized, foreign-body type to scalloped, and langhans and ground-glass appearance to oncocytic histiocytes. lippincott-raven publishers. ? lippincott williams & wilkins, inc.4fig. 2non-langerhans cell histiocytoses: a new unifying concept.zelger, b; sidoroff,

5、 a; orchard, g; cerio, ramerican journal of dermatopathology. 18(5):490-504, october 1996.fig. 2 . diffuse sheetlike infiltrate of juvenile xanthogranuloma (a) with mixture of vacuolated, xanthomatized and spindle-shaped histiocytes as well as touton giant cells (b). lippincott-raven publishers. ? l

6、ippincott williams & wilkins, inc.5fig. 3non-langerhans cell histiocytoses: a new unifying concept.zelger, b; sidoroff, a; orchard, g; cerio, ramerican journal of dermatopathology. 18(5):490-504, october 1996.fig. 3 . diffuse sheetlike infiltrate of adult xanthogranuloma (a) with prominence of s

7、calloped and oncocytic histiocytes as well as giant cells of foreign-body type and with ground-glass appearance (b). lippincott-raven publishers. ? lippincott williams & wilkins, inc.6fig. 4non-langerhans cell histiocytoses: a new unifying concept.zelger, b; sidoroff, a; orchard, g; cerio, ramer

8、ican journal of dermatopathology. 18(5):490-504, october 1996.fig. 4 . diffuse sheetlike infiltrate of mononuclear type of juvenile xanthogranuloma (a) with monomorphous infiltrate of vacuolated histiocytes and a single touton giant cell (b). lippincott-raven publishers. ? lippincott williams &

9、wilkins, inc.7fig. 5. (a)non-langerhans cell histiocytoses: a new unifying concept.zelger, b; sidoroff, a; orchard, g; cerio, ramerican journal of dermatopathology. 18(5):490-504, october 1996.fig. 5. (a) dome-shaped lesion of papular xanthoma: note the faint staining compared with the epidermis or

10、the surrounding connective tissues. (b) higher magnification reveals mixture of histiocytes with prominence of xanthomatized cells. lippincott-raven publishers. ? lippincott williams & wilkins, inc.8fig. 6. (a)non-langerhans cell histiocytoses: a new unifying concept.zelger, b; sidoroff, a; orch

11、ard, g; cerio, ramerican journal of dermatopathology. 18(5):490-504, october 1996.fig. 6. (a) dermatofibroma-simulating lesion of spindle cell xanthogranuloma: note the absence of epidermal hyperplasia and prominent (peripheral) sclerotic collagen. (b) higher magnification reveals prominence of spin

12、dle-shaped histiocytes as well as touton giant cells. lippincott-raven publishers. ? lippincott williams & wilkins, inc.9fig. 7non-langerhans cell histiocytoses: a new unifying concept.zelger, b; sidoroff, a; orchard, g; cerio, ramerican journal of dermatopathology. 18(5):490-504, october 1996.f

13、ig. 7 . papular lesion of xanthoma disseminatum (a) with prominence of scalloped histiocytes (b): note the admixture of xanthomatized histiocytes. lippincott-raven publishers. ? lippincott williams & wilkins, inc.10fig. 8non-langerhans cell histiocytoses: a new unifying concept.zelger, b; sidoro

14、ff, a; orchard, g; cerio, ramerican journal of dermatopathology. 18(5):490-504, october 1996.fig. 8 . diffuse acral infiltrate of multicentric reticulohistiocytosis (a) with prominence of oncocytic histiocytes and giant cells with ground-glass appearance (b). lippincott-raven publishers. ? lippincot

15、t williams & wilkins, inc.11table 2non-langerhans cell histiocytoses: a new unifying concept.zelger, b; sidoroff, a; orchard, g; cerio, ramerican journal of dermatopathology. 18(5):490-504, october 1996.table 2 . histologic, immunophenotypic, and ultrastructural features characterizing different

16、 types of non-langerhans-cell histiocytoses lippincott-raven publishers. ? lippincott williams & wilkins, inc.12fig. 9non-langerhans cell histiocytoses: a new unifying concept.zelger, b; sidoroff, a; orchard, g; cerio, ramerican journal of dermatopathology. 18(5):490-504, october 1996.fig. 9 . m

17、ost characteristic immunolabeling of mononuclear and multinucleate histiocytes in non-langerhans cell histiocytoses: vacuolated (ham56), spindle-shaped (sma), xanthomatized (peanut agglutinin), scalloped (factor xiiia), and oncocytic histiocytes (kim1p); touton (peanut agglutinin), foreign-body type

18、 (kim1p), langhans, and ground-glass appearance (kp1) giant cells. lippincott-raven publishers. ? lippincott williams & wilkins, inc.13fig. 10non-langerhans cell histiocytoses: a new unifying concept.zelger, b; sidoroff, a; orchard, g; cerio, ramerican journal of dermatopathology. 18(5):490-504,

19、 october 1996.fig. 10 . characteristic ultrastructural features in non-langerhans cell histiocytoses: (a) comma-shaped bodies or wormlike particles (asterisk) in benign cephalic histiocytosis, (b) dense bodies (arrows) in xanthoma disseminatum, (c) pleomorphic cytoplasmic inclusions between two dens

20、e bodies (arrow) in multicentric reticulohistiocytosis, and (d) variably sized myeloid bodies (arrowheads) in juvenile xanthogranuloma. bar = 0.5 mum. lippincott-raven publishers. ? lippincott williams & wilkins, inc.14fig. 11non-langerhans cell histiocytoses: a new unifying concept.zelger, b; s

21、idoroff, a; orchard, g; cerio, ramerican journal of dermatopathology. 18(5):490-504, october 1996.fig. 11 . clinical examples of non-langerhans cell histiocytoses outlining variations in appearance according to histopathologic features: (a) early eruptive reddish papules or dome-shaped nodules in ge

22、neralized eruptive histiocytoma (vacuolated histiocytes); (b) fully developed lesions, which are more yellowish, in a solitary juvenile xanthogranuloma as well as (c) a papular xanthoma (xanthomatized histiocytes); (d) hard fibrotic, tan to brownish nodules in progressive nodular histiocytosis (spin

23、dle-shaped histiocytes); (e) reddish-brown tumor of fleshy consistency in reticulohistiocytoma (oncocytic histiocytes); and (f) yellow-reddish confluent lesions of xanthoma disseminatum (xanthomatized and scalloped histiocytes). lippincott-raven publishers. ? lippincott williams & wilkins, inc.1

24、5fig. 12non-langerhans cell histiocytoses: a new unifying concept.zelger, b; sidoroff, a; orchard, g; cerio, ramerican journal of dermatopathology. 18(5):490-504, october 1996.fig. 12 . schematic drawing of classification of non-langerhans cell histiocytoses based upon histopathologic criteria (predominance/mixture of cell types) supplemented by clinical criteria (n