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1、雅思英語(yǔ)閱讀練習(xí)題及答案:第一篇時(shí)間:2010-03-04 16:22:22編輯:能飛英語(yǔ)網(wǎng)發(fā)布:能飛英語(yǔ)網(wǎng)標(biāo)簽:雅思閱讀 英語(yǔ)閱讀 閱讀練習(xí) 閱讀練習(xí)題及答案 內(nèi)容摘要: The failure of a high-profile cholesterol drug has thrown a spotlight on the complicated machinery that regulates cholesterol levels.Why did a promising heart drug fail? Doomed drug highlights complications o
2、f meddling with cholesterol. 1. The failure of a high-profile cholesterol drug has thrown a spotlight on the complicated machinery that regulates cholesterol levels. But many researchers remain confident that drugs to boost levels of 'good' cholesterol are still one of the most pr
3、omising means to combat spiralling heart disease.2. Drug company Pfizer announced on 2 December that it was cancelling all clinical trials of torcetrapib, a drug designed to raise heart-protective high-density lipoproteins (HDLs). In a trial of 15000 patients, a safety board found that more people d
4、ied or suffered cardiovascular problems after taking the drug plus a cholesterol-lowering statin than those in a control group who took the statin alone.3. The news came as a kick in the teeth to many cardiologists because earlier tests in animals and people suggested it would lower rates of cardiov
5、ascular disease. "There have been no red flags to my knowledge," says John Chapman, a specialist in lipoproteins and atherosclerosis at the National Institute for Health and Medical Research (INSERM) in Paris who has also studied torcetrapib. "This cancellation came as a complete shoc
6、k."4. Torcetrapib is one of the most advanced of a new breed of drugs designed to raise levels of HDLs, which ferry cholesterol out of artery-clogging plaques to the liver for removal from the body. Specifically, torcetrapib blocks a protein called cholesterol ester transfer protein (CETP), whi
7、ch normally transfers the cholesterol from high-density lipoproteins to low density, plaque-promoting ones. Statins, in contrast, mainly work by lowering the 'bad' low-density lipoproteins.Under pressure5. Researchers are now trying to work out why and how the drug backfired, something that
8、will not become clear until the clinical details are released by Pfizer. One hint lies in evidence from earlier trials that it slightly raises blood pressure in some patients. It was thought that this mild problem would be offset by the heart benefits of the drug. But it is possible that it actually
9、 proved fatal in some patients who already suffered high blood pressure. If blood pressure is the explanation, it would actually be good news for drug developers because it suggests that the problems are specific to this compound. Other prototype drugs that are being developed to block CETP work in
10、a slightly different way and might not suffer the same downfall.6. But it is also possible that the whole idea of blocking CETP is flawed, says Moti Kashyap, who directs atherosclerosis research at the VA Medical Center in Long Beach, California. When HDLs excrete cholesterol in the liver, they actu
11、ally rely on LDLs for part of this process. So inhibiting CETP, which prevents the transfer of cholesterol from HDL to LDL, might actually cause an abnormal and irreversible accumulation of cholesterol in the body. "You're blocking a physiologic mechanism to eliminate cholesterol and effect
12、ively constipating the pathway," says Kashyap. Going up7. Most researchers remain confident that elevating high density lipoproteins levels by one means or another is one of the best routes for helping heart disease patients. But HDLs are complex and not entirely understood. One approved d
13、rug, called niacin, is known to both raise HDL and reduce cardiovascular risk but also causes an unpleasant sensation of heat and tingling. Researchers are exploring whether they can bypass this side effect and whether niacin can lower disease risk more than statins alone. Scientists are also workin
14、g on several other means to bump up high-density lipoproteins by, for example, introducing synthetic HDLs. "The only thing we know is dead in the water is torcetrapib, not the whole idea of raising HDL," says Michael Miller, director of preventive cardiology at the University of Maryland M
15、edical Center, Baltimore.(613 words nature) Questions 1-7This passage has 7 paragraphs 1-7.Choose the correct heading for each paragraph from the list of headings below.Write the correct number i-ix in boxes 1-7 on your answer sheet.List of Headingsi. How does torcetrapib work?ii. Contradictory resu
16、lt prior to the current trialiii. One failure may possibly bring about future successiv. The failure doesnt lead to total loss of confidencev. It is the right route to followvi. Why its stoppedvii. They may combine and theoretically produce ideal resultviii. Whats wrong with the drugix. It might be
17、wrong at the first place Example answerParagraph 1 iv1 Paragraph 2vi2 Paragraph 3ii3 Paragraph 4vii4 Paragraph 5ix5 Paragraph 6viii6 Paragraph 7iv Questions 7-13Match torcetrapib,HDLs,statin and CETP with their functions (Questions 8-13).Write the correct letter A, B, C or D in boxes 8-13 on your an
18、swer sheet.NB You may use any letter more than once. 7It has been administered to over 10,000 subjects in a clinical trial.8It could help rid human body of cholesterol.9Researchers are yet to find more about it. 10. It was used to reduce the level of cholesterol.11. According to Kashyap, it might le
19、ad to unwanted result if its blocked.12. It produced contradictory results in different trials.13. It could inhibit LDLs. List of choicesA. TorcetrapicB. HDLSC. StatinD. CETP(by Zhou Hong) Suggested Answers and Explanations1 vi 2 ii3 vii 本段介紹了torcetrapib和statin的治病原理,但是同時(shí)短語(yǔ)“in contrast”與之前第二段后半段的內(nèi)容呼應(yīng),暗示了這兩種藥在理論上能相輔相成,是理想的搭配。第一個(gè)選項(xiàng)無(wú)法涵蓋整段意義,故選擇i是錯(cuò)誤的。4 iii 本段分析了可能導(dǎo)致torcetrapibl臨床試驗(yàn)失敗的原因,后半段指出如果以上推測(cè)正確,那么未來(lái)的藥物可借鑒這個(gè)試驗(yàn),設(shè)法避免torcetrapi
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