融資意外地拯救了被遺棄的干細(xì)胞試驗(yàn)

1、融資意外地拯救了被遺棄的干細(xì)胞試驗(yàn)作者:日期：Fundingwindfa11andmarkstemcellrescuesabandonedstemce1ltrialtwoand-a-ha1fyeaCaliforniaialaftissputteringbacker?ltwasabandonedlibycompanythatfreshsetofpackedwithstartedchallenit.Butitnowges,includtdelpofwhetherivedfnervesspina1abruptly1);saidwantedntscellromcompetitors.?Theshuma

2、nembryonicto-cordregrowininjury.in2011byatinstead.oftheedthetimeofocuAsteMen1trCalifornIRM),Buttreat7thatssibithatonsNlow,newia129iatheingtrialacesfieldaimsstem?cellsathattoiscancaItGersessstoppedonofNature479,9;itveralcompa?promisingcancertmeiasPawithMayBiotherapenyuticsafrInstitstate'ieldAster

3、iassinlitybiotechnoforlogyp1ansUS$14.3-millionomthe,a1resurr?grantsoectthatitreceivutehasfirstforRegenerativestem-cell-funmovedonsinpatientindingce2010,Medicine?(Cagency.Geronhasoftreatedspc12heritedinal-coradifferentompanypatientstypeoisdino?startamoreeffectiveness.Andadvancedanothei1stemofGermanto

4、wn,receivedregulatorytobeginhumanron'shumantrialappestsce11sButreing?concernsthecellscompanderivedgulatorsaboutthebeingireportednaleclin0rdcalcou1dnolinjury.ngeranthethenltherapyy小。Newark,asafeStemCells,CalifoarniastemcetrialtentrantMary1and,rovalinofitswasfromhaltedthehumanitpuritymplantseeinga

5、ed,sofratststudies.Theteratomastll,hystudyanditisyeartotothe?fieldpltanstJanuary2013stem-cellproduct.stNeura?Gefirstapprovedto?usembryonicstem?cetwice,oncecitndandmicroscopihathadpredictabi1ityagainaftercystsin7thebeentreatedworrywasthattheuncontrol1edgrowthsofthein?prcyststhatcanformfromfearedsidee

6、ffectofhatthegrowthswere6mbryonictreatment.notteratostemcells,aGeronlatersaid?tmas,andthe?USFoodandDrugAdministrationa1lowedthetrialtoproceed.Butafterinjectingthecel1sinto?fiveofthetenintendedpatients,thecompanysaid1.?Geronchiefterias,hatithadrunfounderMichaelexecutwhichreeeitlastpatineck,willyear.e

7、ntsusingthenosestoseensation?orfuefiviascordrepooutofmoneyforWestandformeriveThomasOkarmathenforboughtGeronb?sstem-cell?hThefctthetriamedAserapcompanyplanthspinal-cord1owdoseofeatdiffthetherentsfirstto?treatthdamage?inthestempeoplewitthce1ls;hhigher?depatientscontinuesdamageatrtedthatprevtotchestnon

8、eserioussideeffectsordeve1opedimmuneResearcherssayformepeofsusedgicallyrGeroncellbyimp1xedmyelinatedinouslacklevel.offromerapythetrytreahadcanunkrestoreanyse1imbs.?Thtedby?Geron,whomAsterOn22May,Asteriasthosefivehadthetreatmentresponsestoit.experiencedthattrialdifferentStemCellsantedembrythecontiisi

9、mportantfromthefetandNeuralstenuationbecause0nleing1ialswhenmature.vitrocells,Theothertowhstemgrowinm.ce1ichinsu1ofittheuses?aty-derived?oneGeronsurlsthat?hadbeeimmatureydifferentiatfetalbrainthatproteionsinthfortheavemultialpr?populatiousdefinewhatdcellsderivedmpaniesfromatee?usingnerve?fibrepartia

10、l1efitissue,survivinneuraleld,gcirwhichmighttissueandproducemakenewsubstancesonnectis?work,b?sayscuitry.?b?Itbecausecel1lineswe，bnow?sverygooofpatients,ingantestdtedhisinvery1lsimi1heneededtoMartinMarsamakela,ahisapprneuroscienoachtisttheUniversityofCalifornia,SanDiego,whoseworkhasshownthatNeuralste

11、mriscellscandevelopintoworkingneuronsandrestore?movementtoratswithcordinjuriesintheneck.?Sti1l,someinthefieldquestionwhether?stemcellsareagoodcandidatefortreating?paralysis.Spinaltraumacandestroyarangeofcells;itcanbedifficulttoaccesstheinjury?site;anddamagecanbeverysevere.Treatingparalysis“maybeaski

12、ngalotmoreofthecellsthantheyarecapab1eofbio1ogica1ly”,saysRobertLanza,chiefscientific?officeratAdvancedCellTechnologyinMarlborough,?Massachusetts,whstem c e lls in twcompany o p ted no t t i n part bee auseichisnowtesting?Smbryo-derivedoeyediseases.?Lanzasaysthathiso?buyGeron'sstem-celltherapy?t

13、hetre a tmen t did n o t seem e f f ean i mal mod el s . So me of thescien t istsen o u g hwh o ?re v i ewedAste rias's sed c on c erns g r ant p ra b o ut theoposaltreatmtothe?CI RMt' s ?effe c tivalsoe ne sexp r en a n i m al“It woulfa n t a sticifthe cel 1wo rk,but Itwoulda 1 so b ew isen

14、 ottoets ays Lanz t ha v ea . ?Mar sal aco untersex p ectations tha t thetooce 1high, ” ls d onoto healthep e o p le ' injur e d t 小revent orte ds p i lives.o r deadth ehatsomesensatinof e e li n g some butnalHedamag ecornotefrof our peopleon; t woin t h ei rwere able towiinc o mpl e t e ly tha

15、t simp 1 y th h ealth ys prea d ing.its st u di ep rev i o u sly h a1 ower1 im b sf ee 1mo r etran s plant. Marsala sees this a sthethatthe rapy i s worki n g.you are going to se etoi mp rovereplacing one s mig hSt e mCell s ?has re ps hav e ?reco ver eandafter“Nobody is com pl e t et hese-一一.力p at

16、i e n t s ,he says. ?Chri s t oph ei ci s tat St anford ?Uni ve r si t yanothertwo?h athe?ce 1s i gnt h atc lai m ingr e co v ery r Scot t ,i n?an ethin Calif o r nia, saysthatbeforescientistscanjudgetheeffectivenessofthe?therapies,thecompaniesmustcompletetheirt r ials.But he wond ers whet herAst e

17、r ias has s u fficient 才esou r ce s t od on its promisemake go o to ?carryGeron' st h e ra p y thr ough to complet i on.Scot t no t es m illion s o f -cord and?othert h at Geron spen t h undreds of d olla r s dev elopin g spinal embr yonic-stem cell t h e r api e s, butmanaged?to tr e a t 0nlyf

18、ive people. The restart e d tria 1 ?wif acee ve n gr e aterscruti n y, and he wor ri e s?t hwould b e a huge b 1 o and policy ana 1 y sts willatifitwereha1ted,itwto?Datients.“Bioethicistswatchingcarefu1ly,"hesays.融資意外地拯救了被遺棄的干細(xì)胞試驗(yàn)具有里程碑意義的干細(xì)胞試驗(yàn)濺射回到生活是在被加州公司拋棄了兩年半以后開始的。但現(xiàn)在面臨的一項(xiàng)新的挑戰(zhàn)，包括一場充滿了競爭對(duì)手的戰(zhàn)場

19、。試驗(yàn)的目的是測試來自于人類胚胎干細(xì)胞的細(xì)胞是否能幫助神經(jīng)再生在脊髓損傷的例子中。它在2011年被GeronofMenloPark,California突然中斷。該公司當(dāng)時(shí)說，它想把重點(diǎn)放在幾種有前景的癌癥治療。哎喲，一家新公司阿斯忒瑞亞Biotherapcutics也門洛帕克市計(jì)劃復(fù)活審判，5月29日收到加州再生醫(yī)學(xué)研究所（CIRM）的14.3美元撥款，國家年代stem-cellfunding機(jī)構(gòu)。但這一領(lǐng)域已經(jīng)自2010年Geron首次治療病人，和阿斯忒瑞亞證明了不再是唯一的治療脊髓損傷的可能性。干細(xì)胞，在加州的紐瓦克的一家生物技術(shù)公司，治療12例在一個(gè)安全的不同類型的干細(xì)胞研究中，并計(jì)劃

20、今年開始一個(gè)更先進(jìn)的試驗(yàn)去測試有效性。和另一個(gè)進(jìn)入這一領(lǐng)域，Neuralstem日耳曼敦，馬里蘭州，獲得監(jiān)管部門批準(zhǔn)，于2013年1月開始人體試驗(yàn)的干細(xì)胞產(chǎn)品。Geron公司的人體試驗(yàn)是第一個(gè)被批準(zhǔn)使用來自干細(xì)胞衍生出來的細(xì)胞。但監(jiān)管機(jī)構(gòu)暫停了兩次11,理由是對(duì)有關(guān)的純度和可預(yù)測性的擔(dān)憂后的被植入的細(xì)胞，并有公司再次報(bào)道看到在顯微鏡下囊腫大鼠脊髓已被處理，令人擔(dān)憂的是，囊腫可能是畸胎瘤-可以從胚胎干細(xì)胞，不受控制的生長。以形成治療的擔(dān)心副作用。Geron后來說這個(gè)增長并不是畸胎瘤，美國食品和藥物管理局允許實(shí)驗(yàn)進(jìn)行。但在注入細(xì)胞的百分之五十的病人中，該公司表示，它已為審判耗盡試驗(yàn)。Geron的創(chuàng)

21、始人邁克爾西和前首席執(zhí)行官ThomasOkarma后來成立了阿斯忒瑞亞。去年收購了Geron的干細(xì)胞治療，該公司計(jì)劃首先治療三個(gè)頸脊髓損傷患者，使用低劑量的干細(xì)胞。然后它會(huì)對(duì)不同的人高劑量治療看看是否可以恢復(fù)任何在軀干或四肢的感覺或功能。先前由Geron治療的在胸線損傷水平的五個(gè)病人，現(xiàn)在繼續(xù)由Asterias跟蹤治療。在三月二十二日，Asterias稱五個(gè)人中沒有一個(gè)是在治療過程中有嚴(yán)重副作用和對(duì)它有高度的免疫應(yīng)答的。研究人員稱，Geron的延續(xù)前試驗(yàn)是很重要的,因?yàn)樗褂靡粋€(gè)類型的細(xì)胞不同于fetus-derived的介紹和Neura1stem使用的。Geron手術(shù)植入胚胎干細(xì)胞，誘導(dǎo)體外生長到成熟有髓神經(jīng)膠質(zhì)細(xì)胞，成熟時(shí)，使神經(jīng)纖維被隔離。其他公司使用部分來源于胎兒腦組織的分化細(xì)胞這可能會(huì)產(chǎn)生新的物質(zhì)，保護(hù)殘存的組織和連接神經(jīng)回路。他們的工作表明，Neura1st