骨質(zhì)疏松治療方案的應(yīng)用評價(jià)

1、 無糖皮質(zhì)激素藥物 等藥物服用史維生素D650IU 尿24小時(shí)皮質(zhì)酮：正常menwomenEffect of Prior Vertebral Fracture on Risk of Subsequent Vertebral FractureAdapted from Lindsay R et al. JAMA 2001;285:320-23051015Incidence of New VertebralFracture (%)No. of Vertebral Fractures at BaselineRR=7.3 (4.4, 12.3)RR=5.1 (3.1, 8.4)RR=2.6 (1.4,

2、4.9)First Year of Study011263%16% Is fracture healing affected by bisphosphonates?手術(shù)后被隨機(jī)分組預(yù)選417人鈣-維生素D3(500 MG/D +400 IU/DAYn=125阿侖膦酸鈉 (70 MG/W) +鈣-維生素D3(500 MG/D + 400 IU/D)n=114治療均在患者能夠保持直立坐位或立位后立即開始通常為術(shù)后2至4 天且均在出院前主要終點(diǎn)事件：全髖骨密度變化Adapted from Cecilia et al.Osteoporos Int (2009) 20:903-9101086420-2-

3、4-6 TH TC IT FN LSChange in BMD (%; 95% CI)Patients treated with alendronate+calcium+vitamin D3 vs. patients treated with calcium +vitamin D3. Bone mineral density (BMD; g/cm2) TH:totalhip, TC:trochanteric, IT:inter-trochanteric, FN:femoral neck, LS:lumbar spineAdapted from Cecilia et al.Osteoporos

4、Int (2009) 20:903-910P0.0005Thank you! 維生素D650IUEffect of Prior Vertebral Fracture on Risk of Subsequent Vertebral FractureAdapted from Lindsay R et al. JAMA 2001;285:320-23051015Incidence of New VertebralFracture (%)No. of Vertebral Fractures at BaselineRR=7.3 (4.4, 12.3)RR=5.1 (3.1, 8.4)RR=2.6 (1.

5、4, 4.9)First Year of Study011263%16% Is fracture healing affected by bisphosphonates?1086420-2-4-6 TH TC IT FN LSChange in BMD (%; 95% CI)Patients treated with alendronate+calcium+vitamin D3 vs. patients treated with calcium +vitamin D3. Bone mineral density (BMD; g/cm2) TH:totalhip, TC:trochanteric, IT:inter-trochanteric, FN:femoral