EHop-016 _Ras 抑制劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEEHop-016Cat. No.: HY-12810CAS No.: 1380432-32-5分式: CHNO分量: 430.55作靶點: Ras作通路: GPCR/G Protein儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 32 mg/mL (74.32 mM)* means soluble, but saturatio

2、n unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.3226 mL 11.6131 mL 23.2261 mL5 mM 0.4645 mL 2.3226 mL 4.6452 mL10 mM 0.2323 mL 1.1613 mL 2.3226 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍福渲魄罢埾扰渲瞥吻宓膬湟?，再依次添加助溶?為保證實驗結(jié)果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據(jù)儲存條件，

3、適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.81 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (5.81 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您邊的抑

4、制劑師www.MedChemESolubility: 2.5 mg/mL (5.81 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 EHop-016Rac GTPase效選擇性抑制劑，在MDA-MB-435細胞中IC50值1.1uM。戶使本產(chǎn)品發(fā)表的科研獻 Mol Oncol. 2019 Jul 17. Appl Microbiol Biotechnol. 2018 Jul;102(14):5965-5975.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Mont

5、alvo-Ortiz BL, et al. Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase. J Biol Chem. 2012 Apr13;287(16):13228-38.2. Dharmawardhane S, et al. Development of EHop-016: a small molecule inhibitor of Rac. Enzymes. 2013;33 Pt A:117-46.3. Castillo-Pichardo L, et al. The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model. TranslOncol. 2014 Oct 24;7(5):546-55.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-379