3-Azido-3-deoxy-5-methylcytidine _HIV 抑制劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE3-Azido-3-deoxy-5-methylcytidineCat. No.: HY-111640CAS No.: 1282040-14-5分式: CHNO分量: 282.26作靶點(diǎn): HIV; Reverse Transcriptase作通路: Anti-infection儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 8

2、3.33 mg/mL (295.22 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 3.5428 mL 17.7142 mL 35.4283 mL5 mM 0.7086 mL 3.5428 mL 7.0857 mL10 mM 0.3543 mL 1.7714 mL 3.5428 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)

3、的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (7.37 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (7.37 mM); Clear solution3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSo

4、lubility: 2.08 mg/mL (7.37 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 3-Azido-3-deoxy-5-methylcytidine (CS-92)種有效的異嗜性病相關(guān)逆轉(zhuǎn)錄病毒 (XMRV) 抑制劑，作于 MCF-7 細(xì)胞，CC50 為 43.5 M。3-Azido-3-deoxy-5-methylcytidine (CS-92) 作于外周 單核細(xì)胞 (PBM)，抑制 HIV-1 逆轉(zhuǎn)錄酶，EC50 為 0.06 M 1。IC

5、50 & Target HIV-1 XMRV0.06 M (EC50, in PBM cells) 43.5 M (CC50, in MCF-7 cells)REFERENCES1. Singh IR, et al. Raltegravir is a potent inhibitor of XMRV, a virus implicated in prostate cancer and chronic fatigue syndrome. PLoS One.2010 Apr 1;5(4):e9948.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-5