Lavendustin-A-RG-14355-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemELavendustin ACat. No.: HY-18963CAS No.: 125697-92-9Synonyms: RG-14355分式: CHNO分量: 381.38作靶點(diǎn): EGFR作通路: JAK/STAT Signaling; Protein Tyrosine Kinase/RTK儲(chǔ)存式: Please store the product under the recommended conditions inthe COA.溶解性數(shù)據(jù)體外

2、實(shí)驗(yàn) DMSO : 250 mg/mL (655.51 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.6221 mL 13.1103 mL 26.2206 mL5 mM 0.5244 mL 2.6221 mL 5.2441 mL10 mM 0.2622 mL 1.3110 mL 2.6221 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制

3、澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (5.45 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (5.45 mM); Clear solutionBIOLO

4、GICAL ACTIVITY1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE物活性 Lavendustin A (RG-14355), 可從Streptomyces Griseolavendus 中分離得到，種有效的、特異性的、ATP競(jìng)爭(zhēng)性的酪氨酸激酶抑制劑，對(duì)表長(zhǎng)因受體 (EGFR) 相關(guān)酪氨酸激酶的 IC50 值為 11 ng/mL 1。 能抑制管內(nèi)長(zhǎng)因誘導(dǎo)的管成，阻斷LTPGABA-A的誘導(dǎo) 2 3。IC50 & Target IC50: 11 ng/mL (EGFR-associated tyrosine kinase) 1.REFER

5、ENCES1. Onoda T, et al. Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus. J Nat Prod. 1989 Nov-Dec;52(6):1252-7.2. Hu DE, et al. Suppression of VEGF-induced angiogenesis by the protein tyrosine kinase inhibitor, lavendustin A. Br J Pharmacol. 1995Jan;11

6、4(2):262-8.3. Gubellini P, et al. Endogenous neurotrophins are required for the induction of GABAergic long-term potentiation in the neonatal rathippocampus. J Neurosci. 2005 Jun 15;25(24):5796-802.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820