腫瘤干細(xì)胞 分子診斷與靶向治療課件

1、Cancer Stem Cells, Molecular Diagnosis and Targeted TherapyFrequently Asked Questions (FAQ)What are cancer stem cells? Why is research on cancer stem cells important?In what tumor types have cancer stem cells been identified?How are cancer stem cells identified?What happens after stem cells are iden

2、tified? Are clinical treatments available now to target cancer stem cells?1. What are cancer stem cells(CSC)?a selectively endowed tumori-genic capacityto recreate the full repertoire of cancer cells of the parental tumorthe expression of a distinctive repertoire of surface biomarkers2. Why is resea

3、rch on cancer stem cells important?weedweed rootcancercancercancercancer-No prairie fire can destroy the grass, it shoots up again with the spring breeze blows.cancer stem cells3. In what tumor types have cancer stem cells been identified?Leukemia Stem CellsBreast Cancer Stem Cells Head and Neck Can

4、cer Stem Cells Adrenal Cancer Stem Cells Pancreatic Cancer Stem Cells Lung, melanoma, myeloma, prostate and thyroid cancers.Table 1 Examples of non-carbohydrate stem cell markers which are also cancer stem cell markers5. What happens after stem cells are identified?how cancer stem cells workidentify

5、 drugs that will kill the stem cells without harming normal cells.6. Are clinical treatments available now to target cancer stem cells?early stagesInitial results are positiveadditional trials in a larger number of patients will be necessary6.2 Figure 1 Oxaliplatin-incorporating micelles are effecti

6、ve for the eradication of cancer stem cells (CSCs).Abbreviations: CSO, chitosan oligosaccharide SA, stearic acid Development of nanomedicine for CSCsDrug-delivery systems for CSCs6.1 Strategies for stem cell-based antibody therapy of cancerFigure. Model of potential strategies for the use of stem cells in antibody