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VITILIGOApril26th,1999Chemistry412RickHelgemoWhatisvitiligo?AutoimmunedisorderGeneticlinkAffects1-2%ofpopulationDifficulttocureHarmfuleffects“Untreated”VitiligoAutoimmunedisorderMelanocytesdestroyed *Melanocyte-specificdifferentiation antigens *Tyrosinase,Dopachromeisomerase (TRP-2),gp100,MART-1ImmunoglobulinGrecognizesTRP-2,causing immuneresponsePossiblelinktocuringmelanoma?GeneticLinksTwotypes-SegmentalandnonsegmentalPolygenicnature,multifactorialinheritanceAutosomalandnotlinkedtoraceorsexLinkedtootherautoimmunediseasesWeaklyheritableCuringVitiligoEffectsLonganddifficultprocess,rarely100%effectiveonindividualAlwaysinvolvessunlightorultravioletlightPhysicalandchemicalmethodsCosmeticsDepigmentationPsychologicalcounseling

ChemicalTreatmentOptionsforVitiligoCorticoidsPsoralens(PUVA)PhenylalanineP-aminobenzoicacid(PABA)Cantharidin,ablisterbeetlesecretionPhysicalTreatmentOptionsforVitiligoTattooing(micropigmentation)AutologousskingraftsSkingraftingusingblistersAutologousmelanocytetransplantationCombinationofSunandSunscreenReferences:“Anti-tyrosinase-relatedprotein-2immuneresponseinvitiligopatients…;” OkamotoT,IrieRF,FujiiS,etal.;TheJournalofInvestigative Dermatology;Dec1998; 111:1034-1039.“AutoantibodiestoTyrosinase-relatedprotein-1detectedinthesera…;”KempEH,WatermanEA, GawkrodgerDJ,etal.;BritishJournalofDermatology1998;139:798-805.“Asystematicreviewofautologoustransplantationmethodsinvitiligo;”NjooMD,WesterhofW,BosJD, BossuytPMM;ArchivesofDermatology,Dec1998134:1543-1549.“ThegeneticsofvitiligoinKoreanpatients;”KimSM,ChungHS,HannSK;InternationalJournalof Dermatology1998;38:908-910.“Ontheassociationbetweenvitiligoandmalignantmelanoma;”LindelofB,HedbladMA,Sigurgeirsson B;ActaDermatologicaVenereologica;199878:483-484.

“Tyrosinaseasanautoantigeninpatientswithvitiligo;”BaharavE,MerimskyO,ShoenfeldY,etal.; ClinicalExperimentalImmunology;1996105:84-88.“Nonsurgicalrepigmentationtherapiesinvitiligo;”NjooMD,WesterhofW,BosJD,BossuytPMM; ArchivesofDermatology;Dec1998134:1532-1540.“Spontaneousrepigmentationofvitiligopatchesdistantfromtheautologousskin…;”MalakarS,DharS; Dermatology;1998197:274.MoreReferences“Treatmentofvitiligowithoralandtopicalphenylalanine:6yearsofexperience;”CamachoF, MazuecosJ;ArchivesofDermatology;Feb1999135:216-217.“UV-dependentmelanocyteplasticity-Thestructure-functionrelationship;”IyengarB;IndianJournalof PathologicalMicrobiology;199639(2):105-109.“Topicalapplicationofamelanotropinanaloguetovulgarvitiligodermo-epidermalminigrafts;” Schwartzmann-SolonAM,ViscontiMA,CastrucciAML;BrazilianJournalofMedicaland Biologic

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