遺傳密碼子翻譯程序

1、遺傳密碼子翻譯程序(圖片選自以及)制作人：山東省聊城第一中學(xué) 張凱【實(shí)踐背景】 隨著人類(lèi)基因組計(jì)劃的進(jìn)展，以及多種生物基因組測(cè)序工作的完成，人類(lèi)跨入了后基因組和蛋白質(zhì)組時(shí)代。雖然DNA是主要的遺傳物質(zhì)，控制著生物蛋白質(zhì)的合成以及生物性狀的表達(dá)，但是，如果要想由DNA的序列推測(cè)生物的性狀，還需要對(duì)DNA與蛋白質(zhì)之間的關(guān)系進(jìn)行研究。而要完成這一研究，首先最基本的就是將DNA序列所代表的蛋白質(zhì)表示出來(lái)。由于DNA上的基因眾多，如果僅僅靠人工翻譯的話(huà)效率很低。因此，在學(xué)習(xí)了相關(guān)的生物知識(shí)以后，我想到了使用計(jì)算機(jī)程序?qū)NA所代表的蛋白質(zhì)進(jìn)行高效，大批量的轉(zhuǎn)換。關(guān)鍵詞：計(jì)算機(jī)程序 遺傳 密碼子 翻譯 蛋

2、白質(zhì)【實(shí)踐目的】 通過(guò)編寫(xiě)計(jì)算機(jī)程序?qū)崿F(xiàn)將遺傳密碼子轉(zhuǎn)換為其表達(dá)的蛋白質(zhì)?！緦?shí)踐步驟】1 如下圖為人教版高中生物必修2課本中的記錄遺傳密碼子與蛋白質(zhì)一一對(duì)應(yīng)關(guān)系的表格。由于其格式不方便編寫(xiě)程序，因此我將其整理成為了另一種形式（見(jiàn)下圖）。(圖片選自)整理后的形式：蛋白質(zhì)遺傳密碼子苯丙氨酸UUU,UUC亮氨酸UUA,UUG,CUU,CUC,CUA,CUG絲氨酸UCU,UCC,UCA,UCG,AGU,AGC酪氨酸UAU,UAC半胱氨酸UGU,UGC脯氨酸CCU,CCC,CCA,CCG組氨酸CAU,CAC谷氨酰胺CAA,CAG精氨酸CGU,CGC,CGA,CGG,AGA,AGG異亮氨酸AUU,AUC,

3、AUA甲硫氨酸AUG蘇氨酸ACU,ACC,ACA,ACG天冬酰胺AAU,AAC天冬氨酸GAU,GAC賴(lài)氨酸AAA,AAG纈氨酸GUU,GUC,GUA,GUG丙氨酸GCU,GCC,GCA,GCG谷氨酸GAA,GAG甘氨酸GGU,GGC,GGA,GGG色氨酸UGG終止UAA,UAG,UGA2 接下來(lái)就是用計(jì)算機(jī)程序解決問(wèn)題。由于C+語(yǔ)言代碼的簡(jiǎn)潔性以及運(yùn)行的高效性，我決定使用Dev C+進(jìn)行工程設(shè)計(jì)。程序的核心代碼見(jiàn)附錄。3 用計(jì)算機(jī)程序制作大規(guī)模輸入文件，測(cè)試程序性能。制作輸入文件的程序如下：#include<stdio.h>char ans5;int main()freopen(&

4、quot;juage.txt","w",stdout); ans1='U'ans2='A' ans3='C'ans4='G' for (short i=1;i<=10000;i+) for (short j=1;j<=4;j+) for (short k=1;k<=4;k+) for (short l=1;l<=4;l+) if (ansj='U' && ansk='A' && ansl='A')

5、continue; if (ansj='U' && ansk='A' && ansl='G') continue; if (ansj='U' && ansk='G' && ansl='A') continue; printf("%c%c%cn",ansj,ansk,ansl); 【實(shí)踐總結(jié)】經(jīng)過(guò)初步測(cè)試之后，程序運(yùn)行情況良好。雖然目前輸入文件仍然是隨機(jī)制作的，但如果將其應(yīng)用于實(shí)踐中，如果通過(guò)DNA測(cè)序儀可以測(cè)出一種生

6、物的DNA序列，進(jìn)而可以將其轉(zhuǎn)換為遺傳密碼子的形式，應(yīng)用這個(gè)程序就可以快速的將其轉(zhuǎn)換為蛋白質(zhì)的形式，從而為研究蛋白質(zhì)與生物性狀之間的關(guān)系提供方便?！靖戒洝?include<iostream>using namespace std;char f='0'char s255;FILE *f1,*f2,*f3;bool end()if (strcmp(s,"UAA")=0 | strcmp(s,"UAG")=0 | strcmp(s,"UGA")=0) return(true); return(false);voi

7、d juage()if (end() if (f='1') printf("%sn","（終止）"); else fprintf(f1,"%sn","（終止）"); return; if (strcmp(s,"UUU")=0 | strcmp(s,"UUC")=0) if (f='1') printf("%sn","苯丙氨酸"); else fprintf(f1,"%sn","

8、;苯丙氨酸"); else if (strcmp(s,"UUA")=0 | strcmp(s,"UUG")=0 | strcmp(s,"CUU")=0 | strcmp(s,"CUC")=0 | strcmp(s,"CUA")=0 | strcmp(s,"CUG")=0) if (f='1') printf("%sn","亮氨酸"); else fprintf(f1,"%sn","

9、亮氨酸"); else if (strcmp(s,"UCU")=0 | strcmp(s,"UCC")=0 | strcmp(s,"UCA")=0 | strcmp(s,"UCG")=0 | strcmp(s,"AGU")=0 | strcmp(s,"AGC")=0) if (f='1') printf("%sn","絲氨酸"); else fprintf(f1,"%sn","絲氨

10、酸"); else if (strcmp(s,"UAU")=0 | strcmp(s,"UAC")=0) if (f='1') printf("%sn","酪氨酸"); else fprintf(f1,"%sn","酪氨酸"); else if (strcmp(s,"UGU")=0 | strcmp(s,"UGC")=0) if (f='1') printf("%sn",&q

11、uot;半胱氨酸"); else fprintf(f1,"%sn","半胱氨酸"); else if (strcmp(s,"CCU")=0 | strcmp(s,"CCC")=0 | strcmp(s,"CCA")=0 | strcmp(s,"CCG")=0) if (f='1') printf("%sn","脯氨酸"); else fprintf(f1,"%sn","脯氨酸&qu

12、ot;); else if (strcmp(s,"CAU")=0 | strcmp(s,"CAC")=0) if (f='1') printf("%sn","組氨酸"); else fprintf(f1,"%sn","組氨酸"); else if (strcmp(s,"CAA")=0 | strcmp(s,"CAG")=0) if (f='1') printf("%sn","

13、谷氨酰胺"); else fprintf(f1,"%sn","谷氨酰胺"); else if (strcmp(s,"CGU")=0 | strcmp(s,"CGC")=0 | strcmp(s,"CGA")=0 | strcmp(s,"CGG")=0 | strcmp(s,"AGA")=0 | strcmp(s,"AGG")=0) if (f='1') printf("%sn","

14、精氨酸"); else fprintf(f1,"%sn","精氨酸"); else if (strcmp(s,"AUU")=0 | strcmp(s,"AUC")=0 | strcmp(s,"AUA")=0) if (f='1') printf("%sn","異亮氨酸"); else fprintf(f1,"%sn","異亮氨酸"); else if (strcmp(s,"AUG&

15、quot;)=0) if (f='1') printf("%sn","甲硫氨酸"); else fprintf(f1,"%sn","甲硫氨酸"); else if (strcmp(s,"ACU")=0 | strcmp(s,"ACC")=0 | strcmp(s,"ACA")=0 | strcmp(s,"ACG")=0) if (f='1') printf("%sn","蘇氨

16、酸"); else fprintf(f1,"%sn","蘇氨酸"); else if (strcmp(s,"AAU")=0 | strcmp(s,"AAC")=0) if (f='1') printf("%sn","天冬酰胺"); else fprintf(f1,"%sn","天冬酰胺"); else if (strcmp(s,"GAU")=0 | strcmp(s,"GAC&qu

17、ot;)=0) if (f='1') printf("%sn","天冬氨酸"); else fprintf(f1,"%sn","天冬氨酸"); else if (strcmp(s,"AAA")=0 | strcmp(s,"AAG")=0) if (f='1') printf("%sn","賴(lài)氨酸"); else fprintf(f1,"%sn","賴(lài)氨酸"); el

18、se if (strcmp(s,"GUU")=0 | strcmp(s,"GUC")=0 | strcmp(s,"GUA")=0 | strcmp(s,"GUG")=0) if (f='1') printf("%sn","纈氨酸"); else fprintf(f1,"%sn","纈氨酸"); else if (strcmp(s,"GCU")=0 | strcmp(s,"GCC")

19、=0 | strcmp(s,"GCA")=0 | strcmp(s,"GCG")=0) if (f='1') printf("%sn","丙氨酸"); else fprintf(f1,"%sn","丙氨酸"); else if (strcmp(s,"GAA")=0 | strcmp(s,"GAG")=0) if (f='1') printf("%sn","谷氨酸")

20、; else fprintf(f1,"%sn","谷氨酸"); else if (strcmp(s,"GGU")=0 | strcmp(s,"GGC")=0 | strcmp(s,"GGA")=0 | strcmp(s,"GGG")=0) if (f='1') printf("%sn","甘氨酸"); else fprintf(f1,"%sn","甘氨酸"); else if (s

21、trcmp(s,"UGG")=0) if (f='1') printf("%sn","色氨酸"); else fprintf(f1,"%sn","色氨酸"); else if (f='1') printf("%s",s);printf("%sn","不是合法的密碼子序列"); else fprintf(f2,"%s",s);fprintf(f2,"%sn",&quo

22、t;不是合法的密碼子序列"); void ready()printf("%sn","遺傳密碼子翻譯程序"); printf("%sn","本程序由山東省聊城第一中學(xué)09級(jí)12班學(xué)生張凱設(shè)計(jì)"); while (f!='1' && f!='2' && f!='3') printf("%sn","1:屏幕輸入 2:文件輸入 3:退出"); printf("%s","請(qǐng)選擇："); scanf("%c"