L-5-Hydroxytryptophan-L-5-HTP-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEL-5-HydroxytryptophanCat. No.: HY-B1716CAS No.: 4350-09-8Synonyms: L-5-HTP; Oxitriptan分式: CHNO分量: 220.22作靶點(diǎn): Endogenous Metabolite作通路: Metabolic Enzyme/Protease儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 mon

2、th溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 100 mg/mL (454.09 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 4.5409 mL 22.7046 mL 45.4091 mL5 mM 0.9082 mL 4.5409 mL 9.0818 mL10 mM 0.4541 mL 2.2705 mL 4.5409 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍福渲魄罢?qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶

3、劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (11.35 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (11.35 mM); Clear solution1/2 Master of Small

4、 Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 L-5-Hydroxytryptophan (L-5-HTP)種天然氨 酸和膳補(bǔ)充劑，可作為抗抑郁劑、欲抑制劑和睡眠輔助劑， 神經(jīng)遞質(zhì) 素的前體， 利平 (reserpine) 的拮抗劑。L-5-Hydroxytryptophan (L-5-HTP) 可于治療纖維肌痛癥、肌陣攣、偏頭痛和腦共濟(jì)失調(diào) 2 3 4 5。IC50 & Target Human Endogenous MetaboliteREFERENCES1. ARVID CARLSSON, et al. 3,4-Dihydrox

5、yphenylalanine and 5-Hydroxytryptophan as Reserpine Antagonists. Nature 180, page1200(1957).2. Caruso I, et al. Double-blind study of 5-hydroxytryptophan versus placebo in the treatment of primary fibromyalgia syndrome. J Int MedRes. 1990 May-Jun;18(3):201-9.3. Thal LJ, et al. Treatment of myoclonus

6、 with L-5-hydroxytryptophan and carbidopa: clinical, electrophysiological, and biochemicalobservations. Ann Neurol. 1980 Jun;7(6):570-6.4. Boiardi A, et al. 5-OH-Tryptophane in migraine: clinical and neurophysiological considerations. J Neurol. 1981;225(1):41-6.5. Trouillas P, et al. Improvement of cerebellar ataxia with levorotatory form of 5-hydroxytryptophan. A double-blind study with quantifieddata processing. Arch Neurol. 1988 Nov;45(11):1217-22.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only