Rac-Brassinazole-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemE(Rac)-BrassinazoleCat.No.:HY-121161CASNo.:224047-41-0分?式:C??H??ClN?O分?量:327.81作?靶點(diǎn):CytochromeP450作?通路:MetabolicEnzyme/Protease儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCOA.溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:50mg/mL(152.53mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM3.0505mL15.2527mL30.5055mL5mM0.6101mL3.0505mL6.1011mL10mM0.3051mL1.5253mL3.0505mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存?式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案，配制前請(qǐng)先配制澄的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分?指該溶劑在您配制終溶液中的體積占?)：1.請(qǐng)依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:2.5mg/mL(7.63mM);Suspendedsolution;Needultrasonic2.請(qǐng)依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(7.63mM);ClearsolutionBIOLOGICALACTIVITY?物活性(Rac)-Brassinazole三唑型化合物，油菜素甾醇(BR)?物合成抑制劑。(Rac)-Brassinazole增加CYP90B在1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemEBR?物合成中的抑制作?。體外研究(Rac)-Brassinazole(compound5)doesnotretardricestemelongation,andretardationisrecoveredbytheadditionofgibberellin(GA3),suggestingthatsuchretardationisduetotheinhibitionofgibberellinbiosynthesis[1].(Rac)-Brassinazol(compound31)resultsinareductionintheeffectonAtKOingibberellin(GA)biosynthesis[2].REFERENCES[1].YKMin,etal.NewLeadCompoundsforBrassinosteroidBiosynthesisInhibitors.BioorgMedChemLett.1999Feb8;9(3):425-30.[2].ErikoSasaki,etal.Uniconazole,aCytochromeP450Inhibitor,InhibitsTrans-ZeatinBiosynthesisinArabidopsis.Phytochemistry.2013Mar;87:30-8.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792