FT-1518-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEFT-1518Cat.No.:HY-107363CASNo.:1313026-58-2分?式:C??H??N?O分?量:394.47作?靶點(diǎn):mTOR作?通路:PI3K/Akt/mTOR儲(chǔ)存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:5mg/mL(12.68mM;ultrasonicandwarmingandheatto60°C)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM2.5350mL12.6752mL25.3505mL5mM0.5070mL2.5350mL5.0701mL10mM0.2535mL1.2675mL2.5350mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請(qǐng)先按照InVitro?式配制澄的儲(chǔ)備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的?式助溶)1.請(qǐng)依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥0.5mg/mL(1.27mM);Clearsolution1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE2.請(qǐng)依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥0.5mg/mL(1.27mM);Clearsolution3.請(qǐng)依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥0.5mg/mL(1.27mM);ClearsolutionBIOLOGICALACTIVITY?物活性FT-1518?種選擇性的，可?服的，有效的新?代mTORC1和mTORC2抑制劑，具有抗腫瘤的活性。IC50&TargetmTORC1mTORC2體外研究FT-1518isanewgenerationselective,potentandoralbioavailablemTORC1andmTORC2inhibitor,andexhibitsantitumoractivity.FT-1518displayssignificantgrowthinhibitoryactivityagainstalargepanelofhematologicandsolidtumorcelllineswithmostactivitiesfallingintolownanomolarrange.FT-1518cuasespotentinhibitionofthemTORpathwaybiomarkers(mTORC1&2biomarkers[pAkt(S473)andpS6(S240/244)orp70S6K),noinhibitionofPI3Kbiomarker[pAkt(T308)]incells[1].體內(nèi)研究FT-1518exhibitsdose-dependentandhighertumorgrowthinhibition(TGI)inmultiplesolidtumorxenografts[1].REFERENCES[1].AlainC.Mita,etal.Abstract137:FT-1518,anewgenerationselectiveandpotentmTORC1andmTORC2inhibitor:aninvitroandinvivoprofile.CancerRes2017;77(13Suppl).McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Te