硫辛酸在神經(jīng)科應(yīng)用課件

硫辛酸在神經(jīng)科的應(yīng)用大連中信藥業(yè)股份有限公司ANZHONGXINPHAF硫辛酸在神經(jīng)科的應(yīng)用1硫辛酸化學(xué)結(jié)構(gòu)式羥基(水溶性、VC)二硫鍵(氧化還原反應(yīng)場(chǎng)所、脂溶性、V-E)OH分子式為C8H14O2S2,相對(duì)分子質(zhì)量為206.33硫辛酸化學(xué)結(jié)構(gòu)式2什么是硫辛酸口硫辛酸是一種存在于線粒體的酵素;其抗氧化能力是VC的100200倍、VE的300-600倍?？诹蛐了峒婢咧苄耘c水溶性特性,在體內(nèi)經(jīng)腸道吸收后可到達(dá)細(xì)胞任何部位,提供人體全面效能?？谑羌?xì)胞代謝通路中,制造能量環(huán)節(jié)不可或缺的成份,在細(xì)胞內(nèi)外抵抗自由基,加強(qiáng)細(xì)胞的修復(fù)能力?？诖龠M(jìn)細(xì)胞吸收營(yíng)養(yǎng),排出廢物,修補(bǔ)受傷部位,增強(qiáng)免疫系統(tǒng)?？诹蛐了峥梢猿ブ亟饘?幫助肝臟清除身體中的其他毒素Ref:Llpolcacld:physiologicmechanismsandindicationsforthetreatmentofmetabolicsyndrome.2019.16(3:291-302Energymetabolbsmandoxidativestress:ImpactonthemetabolcsyndromeandtheagIngprocessEndocrine(2019)29:27-32什么是硫辛酸3硫辛酸藥理機(jī)制綜述口高效抗氧化劑捕捉清除自由基與金屬離子鰲合■修復(fù)受損細(xì)胞NUCLEUS■影響基因表達(dá)口抗氧化劑的抗氧化劑HUMANCELL口影響機(jī)體代謝)米::硫辛酸藥理機(jī)制綜述4硫辛酸藥理機(jī)制——一高效抗氧化劑m捕捉清除自由基硫辛酸具有雙硫五元環(huán)結(jié)構(gòu),具有顯著的親電性和與自由基反應(yīng)的能力。它可清除體內(nèi)常見(jiàn)的羥基自由基什HO)一氧化氮自由基NO)和過(guò)氧化亞硝基(ONOO)等自由基和過(guò)氧化氫(H2O)、單線態(tài)氧(1O2)和次氯酸(HCO等易于產(chǎn)生自由基的物質(zhì)其還原產(chǎn)物二氫硫辛酸還能清除體內(nèi)常見(jiàn)的過(guò)氧化物自由基(RO)和超氧自由基(o2-)。Ref:KurlAnderssonSGE,originandEvolutionoftheMItochondrlalProteome.Microbiol.MolBlol.Rev.A,ColellA,Garcla-RulzC,Fernandez-ChecaJC.Mitochondrialglutathione,akeysurvivalantI-oxIdantAntioxIdRedoxsignal(2009)硫辛酸藥理機(jī)制——一高效抗氧化劑m5硫辛酸在神經(jīng)科應(yīng)用課件6硫辛酸在神經(jīng)科應(yīng)用課件7硫辛酸在神經(jīng)科應(yīng)用課件8硫辛酸在神經(jīng)科應(yīng)用課件9硫辛酸在神經(jīng)科應(yīng)用課件10硫辛酸在神經(jīng)科應(yīng)用課件11硫辛酸在神經(jīng)科應(yīng)用課件12硫辛酸在神經(jīng)科應(yīng)用課件13硫辛酸在神經(jīng)科應(yīng)用課件14硫辛酸在神經(jīng)科應(yīng)用課件15硫辛酸在神經(jīng)科應(yīng)用課件16硫辛酸在神經(jīng)科應(yīng)用課件17硫辛酸在神經(jīng)科應(yīng)用課件18硫辛酸在神經(jīng)科應(yīng)用課件19硫辛酸在神經(jīng)科應(yīng)用課件20硫辛酸在神經(jīng)科應(yīng)用課件21硫辛酸在神經(jīng)科應(yīng)用課件22硫辛酸在神經(jīng)科應(yīng)用課件23硫辛酸在神經(jīng)科應(yīng)用課件24硫辛酸在神經(jīng)科應(yīng)用課件25硫辛酸在神經(jīng)科應(yīng)用課件26硫辛酸在神經(jīng)科應(yīng)用課件27硫辛酸在神經(jīng)科應(yīng)用課件28硫辛酸在神經(jīng)科應(yīng)用課件29硫辛酸在神經(jīng)科應(yīng)用課件30硫辛酸在神經(jīng)科應(yīng)用課件