K-7174-dihydrochloride-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEK-7174 dihydrochlorideCat. No.: HY-12743ACAS No.: 191089-60-8分式: CHClNO分量: 641.67作靶點(diǎn): Others作通路: Others儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) H2O : 15 mg/mL (23.38 mM; Need ultrasonic and

2、 warming)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 1.5584 mL 7.7922 mL 15.5843 mL5 mM 0.3117 mL 1.5584 mL 3.1169 mL10 mM 0.1558 mL 0.7792 mL 1.5584 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 K-7174鹽酸鹽是細(xì)胞粘附抑制劑，能抑制VCAM-1的表達(dá)量。REFERENCES1. Umetani M, et al. A novel cel

3、l adhesion inhibitor, K-7174, reduces the endothelial VCAM-1 induction by inflammatory cytokines, actingthrough the regulation of GATA. Biochem Biophys Res Commun. 2000 Jun 7;272(2):370-4.2. Imagawa S, et al. A GATA-specific inhibitor (K-7174) rescues anemia induced by IL-1beta, TNF-alpha, or L-NMMA

4、. FASEB J. 20031/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESep;17(12):1742-4.3. Shimada T, et al. Unexpected blockade of adipocyte differentiation by K-7174: implication for endoplasmic reticulum stress. BiochemBiophys Res Commun. 2007 Nov 16;363(2):355-60.4. Kikuchi J, et al. The novel orally

5、active proteasome inhibitor K-7174 exerts anti-myeloma activity in vitro and in vivo by down-regulatingthe expression of class I histone deacetylases. J Biol Chem. 2013 Aug 30;288(35):25593-602.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-5895