TAME-hydrochloride-DataSheet-生命科學試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemETAME hydrochlorideCat. No.: HY-13255ACAS No.: 1784-03-8分式: CHClNOS分量: 378.87作靶點: Ser/Thr Protease; APC作通路: Metabolic Enzyme/Protease; Cell Cycle/DNA Damage儲存式: Powder -20C 3 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMS

2、O : 155 mg/mL (409.11 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.6394 mL 13.1971 mL 26.3943 mL5 mM 0.5279 mL 2.6394 mL 5.2789 mL10 mM 0.2639 mL 1.3197 mL 2.6394 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內實驗 請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實驗結果的可靠性，體

3、內實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.58 mg/mL (6.81 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.58 mg/mL (6.81 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oi

4、lSolubility: 2.58 mg/mL (6.81 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 TAME hydrochloride種絲氨酸蛋酶抑制劑，也作絲氨酸蛋酶、胰蛋酶、纖溶酶和凝酶的底物1 2 3。TAME hydrochloride是后期促進復合體 (APC) 的抑制劑，它結合到 APC 并通過 Cdc20 和 Cdh1 防其被激活 3。IC50 & Target Serine protease 2Anaphase-promoting co

5、mplex (APC) 4REFERENCES1. Weinstein MJ, et al. Differential specificities of the thrombin, plasmin and trypsin with regard to synthetic and naturalsubstrates andinhibitors. Biochim Biophys Acta. 1972 Feb 28;258(2):577-90.2. Jessop JJ, et al. Effects of serine protease inhibitor, TAME, on IL-1 beta i

6、n LPS-stimulated human monocytes: relationship betweensynthesis and release of a 33-kDa precursor and the 17-kDa biologically active species. Inflammation. 1993 Oct;17(5):613-31.3. Collard JG, et al. Effect of proteolytic inhibitors on growth and surface architecture of normal and transformedcells.

7、Exp Cell Res. 1974May;86(1):75-80.4. Zeng X, et al. Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in theabsence of spindle damage. Cancer Cell. 2010 Oct 19;18(4):382-95.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use